Personally, if I'm going to haul around something the size, shape, and weight of a rifle, I'd rather it be more than just an oversized handgun.
The .357 Sig might make a decent round for a subgun (better penetration, bottleneck means it feeds really well), for civilian purposes, the NFA limitations end up working against pistol caliber carbines. For reloading, I imagine the .357 Sig might be no easier to do than .223/5.56 (I only reload shotshell and straight walled pistol rounds right now, so somebody might be able to correct me on this one), so again, there isn't much benefit.
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