Just wanted to follow up with this, after a few weeks hiatus I finished my project. I used some of the input from HiBC and Doc Hoy much obliged.
The journey was long and painful for a garage project but I prevailed. I made a fence and block to drill the holes, and clamped the workpiece later per Doc Hoy's advice after centering the drill per HiBC's advice. This isnt CNC precision mind you but in the end precise enough to barely discern by eye. I can now take pride in making my own grips that dropped right onto the pistol perfectly. The hardest part of this project is positioning the thru holes 3.074" apart and centering the cbores over them and not drilling the cbores too deep. I love the look and feel of the slim grips. For this set I switched to oak material with a light "Sedona Red" stain and seal for my full size govt...