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you have to admit they are what the guns were designed for sightwise.
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In a pistol, bullet design has little to do with the point of impact at typical handgun distances. That's determined by velocity and bullet weight. Regardless of bullet profile, all bullets of a given weight and fired at roughly the same velocity should have very similar points of impact from a given pistol.
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BUT its better then mace, pepper spray, tear gas, stun guns and tasers are.
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A firearm will generally have more deterrent effect than non-lethal/less-lethal means, but that's neither here nor there as far as this discussion goes. There's really very little reason to choose LRN in a revolver for self-defense. Other bullet profiles are widely available--probably even easier to find for that matter.