[SRH78]

As far as today's main self-defense handgun calibers, when you're using modern hollow points there really is only a marginal difference between them. I remember when I asked a co-worker of mine whether he preferred 9mm, .40, or .45; he used to work as a professional instructor and has trained with and is friends with Massad Ayoob, so I wanted to hear his opinion. He said, "They all suck, so pick the one you shoot best."

Great answer!