Just my anecdotal experience, for what it is worth.
I have had (continuously) a Python since 1981. Others have come and gone. When I was young, I shot that Python a whole lot, and as I did with other revolvers in the eighties, I stopped counting fired rounds at 6,000 as it seemed pointless at the time to keep counting- that was well over 20 years ago. 90% of that fodder was Remington's 125 grainers.
I still fire quite a bit that Python. Now I mainly use mild reloads. I'd venture that the gun has seen well over 10.000 rounds. Perhaps quite a bit more. And no, it has not (as yet) required any service. It is still tight as a drum, and a real pleasure to shoot. Knock on wood.
BTW, that Python was used (but as new) when I got it.
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