FA's are made very precisely and to tight tolerances. Chambers are minimum spec. As long as you thoroughly clean the chambers when going from .45Colt to .454, it'll be fine.
Or you could just load .454 brass to whatever power level is desired.
Quote:
You could get a couple of Ruger Blackhawks for less than one FA.
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And have half the gun. If what you want is an FA, no Ruger will do.