LP,
If as you say, the wind is in a neutral direction, and you're in flat country where its not swirling or changing directions 3 times between you and the target..well, sure, why not.
Any kind of cross wind kills that shot though. A 10 mph cross wind where you are will not be the same out at 500 yards. It may be gusting out there at 15 mph or dead still.
You seem to know your business so I'll not flog a dead horse (or deer).
I live in an area where one is tempted to take extreme shots, open grassy mountainsides. The results are often ugly no matter how well you think you know your trajectory and bullet drift because the wind is so unpredictable flowing around high hills and mountains.
This terrain is probably "worst case", but wind is never of steady velocity or direction in any area.
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Keith
The Bears and Bear Maulings Page:
members.xoom.com/keithrogan