There was a thread about this not long ago. When chambering a round from the magazine, in most autos the case rim slides under and up into the extractor. When manually loading the round into the chamber and releasing the slide, the extractor hits the back of the case rim and rides over it rather than the case sliding up into it. It is said that this can put excess wear and stress on the extractor overtime. Certain guns like the Beretta 92 are designed to be manually loaded if need be, and is perfectly safe for the extractor to drop a slide on a manually chambered round.
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