Considering the threat from 2 legged varmints today, you might consider something like one of the G20 10mm Glocks. Enough power for Denmark to use them to arm their Sirius Patrols in Greenland with to defend against polar bears but also a practical fighting weapon as opposed to doing it cowboy style.
My choice anyway...with full power loads.
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Above is based on the opinion of a 20 year Small Arms Marksmanship and Training Unit USAF instructor with more than 30 years in competitive shooting sports. Your mileage may vary.
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