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In training I was taught mozambique drill then if those hit, and failed to stop, to put 2 in the groin. I believe this in such an order to be successful but, one straight to the groin in a small caliber first shot if you were being followed or you were in danger, especially if the assailant had a knife, imagine if he or she got away ditched the knife, and you told the cops you tried to shoot him/her in the groin... Talk about your possible law suit. Sorry I agree, major arteries would be good but I would say this would be one of my last resorts as in they are not walking away from the situation.
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