Here are penetration figures showing what is expected penetration in soft tissue (no bone). 9mm numbers are included just for fun. Note that both calibers penetrate to similar depths--about
2.3 FEET.
http://www.firearmstactical.com/imag...30gr%20FMJ.jpg
http://www.firearmstactical.com/imag...0US%20M882.jpg
If you're talking any typical defensive handgun caliber & scenario, the penetration of FMJ ammo out of a typical SD caliber is sufficient to fully penetrate a human from any reasonable angle if a bone is not hit. If a bone IS hit, (which is very likely) then there's no way to make a prediction.