The 22 lacks the power to immediately stop an attack. If you use a 22 for defense, you run the risk of getting shot before the threat has been eliminated. The larger centerfire rounds have a much better chance of giving you that quick, ultimate knock down power. Im not saying that you cant defend yourself with a 22, but you stand much better odds with something more powerful. If a 22 is all you have, by all means, use it. But if you have something, anything more powerful than a .25ACP, use that instead.
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