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If you are using cut down .223 or similar brass, make sure the case necks are trimmed/reamed to be of normal thickness for a pistol case. If they are too thick, the round won't chamber and if it does the pressure can go pretty high because the neck can't expand to release the bullet. (This issue is usually addressed in terms of rifles, particularly in regard to firing 8x57js in an unaltered 8x57j chamber, but the same is true in a pistol.)
Jim
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