[fisherman66]

Tissue damage is a function of the bullet and the speed at which it travels. Select a moderately stout bullet and one will get one .375 hole and a fist sized hole at the other side at the biggest. Select a lightly built bullet and get the same first hole, and a larger hole on the other side (all things even). Hit bone and all bets are off for the lightly constructed bullet's behavior, but the stout one breaks the bone without the higher likely hood of breaking up.

I'm not about to be critical of one's rifle selection, but that's way to much gun for my hunting needs. I would love to have one if I ever go to Africa or Alaska, but a bolt gun or double would probably be my first choice (even thought I'm a #1 fan and own one.) An Osage Orange, Ebony or Mesquite stock (think heavy) would complete the package.