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Its mentioned above aswell, but be carefull loading that thing with to little powder. That goes for all "long" cased calibers....You could mess your self up a bit... Iv seen a broken Brno 602, belive it or not. I have a Brno 602 375H&H myself. So I know that the lock is rock solid. The poor guy that cracked his gun got what we call a double ignition. Some of the powder was ignited by the primer. Then the rest of the powder ignited way to fast because of the initial powder blast. Dynamite....Doesent happen too often, but it happens.
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I called
Hodgdon Powders (technical) this afternoon and queried them about this. They intimated that this phenomenon had not ucurred during their labratory testing of IMR "Trail Boss" utilized as reduced loads in large capacity rifle cartridge cases as prescribed
on this Hodgdon (PDF) page