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as long as the muzzle velocity isn't vastly different I can't imagine the POI being so far off from the factory loads that it would matter.
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Hopefully someone will chime in if I'm wrong, but I think that if you have two identical bullets that leave the muzzle of the same gun at identical speeds, their external ballistics should be the same.
I do realize that the two loadings may have very different pressure curves, and that it might be possible for a load that duplicates a factory load's muzzle velocity to subject the gun's internals to unsafe pressures.