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Uniformity in your ammo is the goal in handloading for accuracy. The brass casing is a pressure vessel of a given dimension or volume. To the extent that you maintain consistent volume in your pressure vessel, and consistent charge weights and seating depth, you are well on your way to consistent ammo that will shoot accurately.
From a safety perspective, variables in the volume of your pressure vessel, or in bullet weight or diameter, can increase pressures to unsafe levels. For low pressure cartridges such as 45 ACP, the margins of safety are greater, so changes in the volume of your pressure vessel will be less likely to have a catastrophic effect. My suggestion is that if you are using mixed headstamps, find a powder charge of a slower burning powder, in the middle of the range which is adequate to cycle the action, to build in a little cushion of safety.
If you were to use max charges of fast burning powder, with mixed headstamp cases, and heavy for cartridge projectile, you are treading closer to disaster than you might be aware...
My $.02. Hope this helps.
Regards,
Stubb.
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