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"That manual is for people in the profession of killing people and breaking things, armed with appropriate tools and (hopefully) trained to hit what they aim for. And additionally not concerned about criminal and civil charges for "executing" someone, or issues of overpenetration. "
Still. Presumably, they know what they're talking about...and if I'm going to shoot someone in self-defense, a shot that "guarantees immediate and total incapacitation" is definitely better than one that doesn't.
Further, the skull is the most solid bony structure in the human body, and therefore is best suited to preventing overpenetration of a bullet.
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