The best caliber advice I ever got was: "carry whatever YOU can shoot the best". We can break down balistics all day long, but all in all, get what you shoot the best. If you think about a practical, real world defensive situation, your target is at cross the room distance. At that close of a range, will it really matter a .40 vs .45? Either round will do the job quickly and effectivly. There's pros and cons to either round, so just get the one that you shoot the best and are the most comfortable with.
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