.500 S&W Overall length 2.250 in
.45ACP Overall length 1.260 in
Since many people have complaints about the circumference of a 1911 grip which was designed for the .45 ACP; imagine if you added the needed amount to the circumference for the .500 S&W! Very few people could grip the handgun.
This assumes a design which has the magazine contained in the grip of the handgun, and not something like a boomhandle design.
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NRA Life Member - Orange Gunsite Member - NRA Certified Pistol Instructor
"When plunder becomes a way of life for a group of men living together in society,
they create for themselves in the course of time a legal system that authorizes it and a moral code that justifies it." Frederic Bastiat