If you were working in a vacuum???
When you seat the bullets, then you might very slightly reduce the pressure of the load when fired - air pressure 14.7psi at sea level, so, loaded in a vacuum, that <15lbs pressure (approx) will not be there. So a very slight difference when the powder burns. about 15psi.
Loaded ammo placed in a vacuum will have no effect, as the ammo is basically air tight. Over a long enough period of time (years/decades?) it might, but if it did, all that could happen is the loss of the ~15psi abient air pressure.
Vacuum packing ammo is to ensure all the moisture in the air is removed (by removing the air), enhancing long term storage.
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All else being equal (and it almost never is) bigger bullets tend to work better.
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