#1 Get Nosler Partition bullets. Failsafes are great on smaller game but not as good on heavy, thick bodied game. Bullet tends to expend all energy on impact, and doesn't penetrate as well as the partitions.
#2 Big concern if you have to trail a wounded animal. Entrance wounds don't leave a very good blood trail to follow.
#3 Can't think of a reason. Ammunition is to expensive NOT to.