I think they are much more realistic in .44 Rem mag.
Ammo will be much easier to find, recoil will be enjoyable and it can always be converted to .50 AE later on. The DE uses the same bolt for .44 and .50, so caliber conversions aren't too expensive.
.357 uses a different bolt and recoil springs than the other calibers, so conversions to or from .357 cost a lot more.
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