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I'm currently loading 5.1 gr. of Unique under 125 gr. Hornady bullet and yes the case is mighty full (90%). It appears that the bullet may, in fact, crush the powder just a bit but the respone of these loads on the range is very acceptable. I haven't experienced any over pressure signs - having shot 300 of these rounds.
All legal disclaimers apply here, your mileage may vary....etc.
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The devil's strategy is to trivialize human existence and to isolate us from one another while creating the delusion that the reasons are; time pressures, work demands, or economic anxieties.
Dr. Phillip Zombardo. "The Age of Indifference"
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