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I haven't taken a deer with a .45 acp, but I have taken an 85 lb mountain lion. I used a 230 grain federal hydroshok. The lion dropped like a stone at the shot and didn't quiver. The houndsman later told me it was the quickest kill he's seen. That's my only big game kill with a .45 acp, but based on it, I wouldn't hesitate taking a deer with it.
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