ya... I have an Alaskan in 454... heavy gun, big Cylinder... I can overlook the Cylinder diameter if the gun were lighter, & as it is, I can load 45 Colt in the 454...
even thought about ( albeit not seriously ) of ways to lighten the Alaskan... I.E. drill "lightening" holes in the under lug, possibly remove material from the grip frame area, etc... but at the cost of a NIB Alaskan ( as mine was purchased ...)... I'd have a hard time machining it full of holes