Yeah, couple of points.
Yes, it's built on the 44Magnum-class frame. Yes, it can take very gnarly 45LC+P. Some of the factory loads exceed the power of most 44Mag ammo.
The bad: Well, shoot it
. If it shoots good, enjoy.
If it doesn't...you'll either have "point of impact" problems or group size. Or if you're having a very bad day, both.
Point of impact is corrected with a small file and some care. Since this is a fixed-sight gun, pick a bullet weight range and dial in your elevation to match. If you're into very heavy loads (300gr or more) you might have to add a taller front sight, dovetailed to the barrel or on a custom base. I personally would see how it shoots with 270s - if it's OK there, it'll be decent with anything between 250 and 300.
On windage, if it's off, filing a bit of the inside of the rear sight can help if it isn't too bad.
Groups: if the group size is ugly, you need to sort out why. Start with the "revolver checkout" post, this forum, stickied on top. That'll tell you if anything is very screwball. If that's OK, next thing, push soft lead slugs through each cylinder chamber and measure them. They may be too small, and/or they may vary between chambers. Somebody like this can do a cheap correction:
http://www.cylindersmith.com/