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I run 15.0 grains of H110 behind a 158gr XTP with zero trouble. In my 327 TRR8 it is very controllable and quite accurate. No pressure issues either.
Personally, I'd rather back my loads off a half grain or so and be sure it's safe (and the extra velocity one might get isn't all that big a deal to me) than potentially push the envelope and have a problem.
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