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If you want to kill an attacker put big holes in their chest or head. Or both. The bigger the hole, the faster they are going to bleed out, or the more damage the object making the hole is going to do on it's trip inside.
Even with good shot placement, a .22 is not going to perform as good as a larger caliber.
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"What is play to the fool and the idiot is deadly serious to the man with the gun."
Walt Rauch,Combat Handguns, May '08
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