With 2400 stick with regular primers if possible. Primer selection is generally powder dependent. As said above H110 needs a magnum primer. So does IMR 4227.
To complicate things, some powders really don't care what primer you use ... like Unique or Green Dot. A chronograph is helpful here. I've found sometimes while either work, one will cause the ES to be better, or a bit more accurate. Other times I found were using a Magnum primer increases velocity over 100fps.... Wooh, Can you say more pressure? So depends.... but in general the powder you use dictates what primer (regular or magnum) you use.
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A clinger and deplorable, MAGA, and life NRA member. When guns are outlawed, only outlaws will have guns. Single Action .45 Colt (Sometimes colloquially referred to by its alias as the .45 'Long' Colt or .45LC). Don't leave home without it. That said, the .44Spec is right up their too... but the .45 Colt is still the king.
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