I'd give the Hornaday 220gr FP bullet a look. I've decked hogs 2 men couldn't move with that bullet. RE 7 is yer friend and a max load of it will get ya about 2200'ps. Accuracy tops any other powder/bullet combo out of the three I have. The 375 Win. is probably the most under rated cartridge out there. Now if only I could find a NIB Marlin 375!
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