I have a Colt New Agent in a Crossbreed supertuck, an it has never come off safety yet (it has the normal size safety, but i've never rappelled out of a helicopter
). My wife also keeps a Sig P238 in her purse in it's own compartment (which works surprisingly well), and she has kept it in condition 3 for a while, and ha recently moved it to condition one after seeing that the safety has never came off on her. I'm buying an integrated holster as well, to ensure that it can stay that way.