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Sadly, folks under stress will do what they are taught and if they are taught to try to shoot for the region between the nipples and chin or nipples and neck, they will likely do that regardless of the orientation of the person they are attempting to defend against.
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I think this is a bit of a stretch...I believe even the inexperienced will generally shot for COM regardless of the bad guy's position and orientation. Upon what are you basing this assumption?