When all the 9mm, 45, 40 and .22LR is completely dried up and banned by "I'm dumber than a 6th Grader" Feinstein, you might wish you stocked up on a bunch of .25.
It's probably the only cartridge that is not on her "hit list".
The .25 auto is from a different era - vest-pocket pistols were all the rage. Ballistically its not all that different from a 32 S&W which was used in many little top break revolvers popular around the same time. It probably fed more reliably than .22LR and in its day was more reliable than .22LR. My understanding was that the .22LR didn't feed very reliably in auto pistols until sometime around when Ruger came out with its Mark I. Well, those are my thoughts.
The real question is why is .25 auto still around while .32 S&W is pretty much long gone?