Obviously if set up aids in some kind of physical handicap, that's ok.
About a round in the chamber with safety on and your dawg! Tom was worried about drop safety and kids. However, he did tell of a guy who had a loaded shotgun under his bed. Somehow, Fido stepped on the trigger and blew the guy's foot off. Don't know if the safety was on or Fido took it off.
There have been a few dogs shooting their owner with a long arm that I recall.