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Does a .45 caliber round loose all its quote ".45 punch" being fired from anything shorter than a 5' barrel? Kind a like a 357 round being fired from a snub nose.
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The majority of it's "punch" as people relate to it is more from the diameter and bullet weight.
The loss of velocity, if any, is not enough to lose all it's "punch" or even enough to make a big difference..
So my answer would be no it would not lose all it's punch.