ONLY researching the internet (you know where that gets you) and talking to friends that own both:
Damage: 50BMG by a mile.
Cost: 50BMG by light years
Popular: 50BMG....subjectively
Availability: Depends on what you mean...reloading components, milsurp ammo, guns chambered in it....
One's you didn't ask but I have to be a smart aleck:
Accuracy definitely goes to .338Lapua in the target arena, especially if you're heading out in the realm of 1200+
The .416 Barrett has been getting accolades for being supreme in accuracy at looong distances...
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