Having personally witnessed a single action large bore (40 cal or larger) revolver successfully used to defeat multiple assailants using pump shotguns and semi-auto rifles, I consider them to be entirely up to the task of personal defense against 2 or 4 legged assailants.
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"Government is not reason; it is not eloquent; it is force. Like fire, it is a dangerous servant and a fearful master."
--George Washington
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