I do that but I am a revolver fan.
I have a lot of 357 magnum guns from a Derringer to a Coonan Classic to multiple revolvers to a pair of Marlin lever actions.
I am still looking for a "best" load for hunting with my Marlins.
They all get the same ammo.
The same goes for the 45/70. I load what works best in my Marlin then just use that load in my BFR. The BFR can take the pressure.
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Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...
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