[Seaman]

"I think it might be difficult to fly fish with a shotgun/rifle hanging on my back. Although I don’t mind having a shotgun/rifle with, I would bet that most of the time it would be resting on tree on the shore while I fish. "

Same thing would happen to me. Bears like fish, they are not shy about taking your catch.

"Should I go to Alaska with the two guns, the Ruger Redhawk 44 and one of the 454’s?"

One is enough. My trail gun is a 44Mag S&W 29, 3" barrel, heavy duty non-fluted cylinder, just weighed it, 45 ounces empty, right about the weight of a Ruger Alaskan. I would go with the 454 Ruger Alaskan.

I've had longer barreled 44 Mags, but they are more suited for hunting, not close range self defense. A big bore snubbie is the ultimate rough and tumble gun.

Since you are already shooting 10mm you will likely be able to handle a big bore handgun. Its all about riding the recoil.

If you wind up dancing with a brownie, you won't feel the recoil.

I would not shoot 44 spl or 45 Colt thru the respective guns, this just cruds up the chambers, more cleaning required + wear & tear.

Best of luck to you, enjoy your time in the last great frontier.