Wing chun with modifications. But honestly you won't be able to do much against serious attack without weapons. I have a friend who has been in wheelchair his whole life and we have discussed some of these things a bit.
If your in a chair or on crutches you would most likely be knocked to the ground early.
I would suggest highly trained BIG dog plus multiple guns and knifes. The dog doesn't need to be more than a companion dog as long as it is big. A personal protection dog might be an option also.
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