The 300wm has more knock down power and less drop then any 308 or 06 at any distance. If you had to defend your life or the life af a client from a charging/wounded animal which would you rather have? To me the real issue is recoil, if you don't like or can't shoot a heavy recoiling rifle then a 308/06 would be a better choice but if recoil is not an issue then the 300wm is a great round. The same can be said for the 7mm mag vs 7mm08, 308 vs 30-06, 270 vs 270wsm. Love mine.
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