I say high KE rounds like the .357sig or .40S&W or 10mm have value because if you shoot at a human being the shock & impact of the entry wound be higher than a smaller, lower KE level round.
Blood loss, shock and trauma can cause a subject to stop fighting. Keep in mind that drugs or alcohol may also prevent a rapid reaction too.
Even a .44spl, .45LC or .45acp rd may not stop a spun-out, hyper drug addict.
Clyde