Strongly recommend the 550B. Changing between calibers is a breeze, provided you have the tool head ('bout $12) with the dies installed and set for each caliber.
I don't see the benefit of buying additional powder measures because with a little practice you can dial in between powder weights quickly.
That said, it takes me about 10 minutes to switch between, say 45ACP and 223Rem, and that includes a good cleaning of the press, switching the primer from large to small, changing the base plates and getting the powder throw right.
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