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I think its like big game hunting. You can hunt elephant and cape buffalo with a .375 or 9.3x62, most people do. But there are hunting rifles and stopping rifles when it comes to big game. Stopping rifles are often in .458 Lott and larger. You don't use expanding bullets when hunting these animals so even a slightly larger hole makes a big difference. Of course I've seen videos of a cape buffalo soaking up just under ten of these .45 caliber slugs and a few larger.
So your .22 caliber high powered rifle would be a hunting rifle if you're a good shot (as long as extreme ranges aren't expected), but something larger might be desired in case that thing decides it doesn't want to die just yet.
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