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No experience here with the spray-on or powdered lubes. They have their advocates, too.
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Never tried powdered lubes either.
The spray on, I use for .45-70, .223, .30-06, .308, 6MM Remington, .303 Brit. etc. I've also used it on .44 Magnum and .45 Colt before I got a carbide die.
But one thing to remembner,
ALL lube needs to be cleaned off before firing! I know of one manufacturer that says their lube doesn't need to be cleaned off. To that, I answer BULLS&*T!
ALL lube needs to be removed. And that's according to several manuals and my personal (unfortunately) experience.
For loading the big magnums, and for case forming, Imperial can't be beaten, although the greasy RCBS stuff works very well also.