Are you talking about shooting or carrying?
Shooting-wise, I sometimes use a 6-1/2" S&W Model 629 (N-frame .44 magnum) for Bullseye, which requires one hand unsupported precision shooting at 50 yards and 25 yards for a total of 90 shots. Yes, the gun is heavy and front-heavy (48.3 ounces empty, over 50 ounces loaded), but if you pay attention to keep the nose up it can be done. I work out my arms and wrists regularly to maintain the needed strength to handle such guns with minimal shaking.
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