I do that very thing. 230-grain lead flatpoints, over Titegroup in a .45LC case. Never a problem, but as Dillonhelp says, you have to watch OAL.
Watch for accuracy issues in your gun as well. A lot of .45LC guns like .454 bullets, and .45acp bullets are likely to be .451 or .452. No dangers, but accuracy could potentially be less than ideal, much like with the old .357/9mm convertible Blackhawks.
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