I know I'm just an "old lady," but the first rule of reloading is to ALWAYS start with the lowest starting load you can find.
Next, if you can find HP38, it is the EXACT same powder as 231 and it is cheaper.
If you want ACCURATE .45ACP loads, try 231/HP38, AA2, and Bullseye.
There are many recommendations for Clays, TiteGroup, WST, and N310, but none of them have been as consistently accurate as the three I mentioned. Since I live in my own world where accuracy is the first and almost ONLY reason to choose a powder, I can't speak for "cleanliness" or smoke.
Unique often does fantastic at 5.0gn and 6.0gn, in several cartridges and with several bullet weights.
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