I'm also a lefty, but even if I were a righty, don't think I could characterize a gun that required a reach to rotate the safety through 180 degrees as "almost perfectly ergonomic".
Of course, I also find the Luger to be one of the least "natural" pointers I've ever shot, so maybe my hands aren't natural?
My dad had two Colt hammerless models, and a Savage 1907, but carried the Beretta when he traveled.
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